Bioactive Small Molecules
Medchemexpress LLC SAG Human P.pastor 50ug
Recombinant human SAG (Smoothened agonist) expressed in Pichia pastoris and purified with a histidine tag. Supplied as a purified protein for research use in hedgehog pathway activation and cell signaling assays; suitable for in vitro studies. Handle and store according to supplier recommendations to maintain activity and stability.
- Recombinant human protein expressed in Pichia pastoris.
- His affinity tag for facile purification.
- Suitable for in vitro hedgehog pathway and signaling assays.
- Supplied in microgram quantities for experimental use.
- Store and handle according to supplier recommendations to preserve activity.
Medchemexpress LLC Imazalil sulfate | 58594-72-2 | 99.6% | 5 G
Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. It is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
- Fungicide
- Oral activity
- Strongly activates mPXR but not mCAR in mouse liver
- Commonly used to protect various agricultural crops against fungal attack
- Induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder
Cayman Chemical Linuron, Purity: ≥95%, CAS: 330-55-2, 100 mg
A phenylurea herbicide; inhibits the androgenic effect of dihydrotestosterone in MDA-kb2 breast cancer cells (IC20 = 1.74 µM in a reporter assay); inhibits testosterone-induced growth of the seminal vesicles, ventral prostate, and levator ani and bulbocavernosus muscles in castrated rats at 100 mg/kg; post-emergent application to carrots controls the growth of the weeds redroot pigweed and lambsquarters
ABclonal Technology Chk2 Rabbit pAb
This gene encodes a cell cycle checkpoint regulator and putative tumor suppressor. The protein contains a forkhead-associated domain crucial for activation in response to DNA damage and replication blocks. Upon activation, it inhibits CDC25C phosphatase, preventing mitosis entry, and stabilizes the tumor suppressor p53, leading to G1 cell cycle arrest. It also interacts with and phosphorylates BRCA1, enabling DNA damage survival. Mutations in this gene are associated with Li-Fraumeni syndrome, linked to TP53 mutations, and increase the risk of sarcomas, breast cancer, and brain tumors. This nuclear protein belongs to the CDS1 subfamily of serine/threonine kinases, and several isoforms are produced through alternative splicing.
Medchemexpress LLC HY-133026 100mg Medchemexpress, N-Acetylcarnosine CAS:56353-15-2 Purity:>98%
Medchemexpress, HY-133026 100mg N-Acetylcarnosine CAS:56353-15-2 N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in human cataracts. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Thonzylamine | 91-85-0 | 98.1% | 25 MG
Thonzylamine is an orally active H1 histamine receptor antagonist with good antihistaminic and antianaphylactic properties. It is used for the research of various hypersensitivity diseases, nasal congestion, and allergic conjunctivitis.
- Orally active H1 histamine receptor antagonist
- Good antihistaminic and antianaphylactic properties
- Suitable for research on hypersensitivity diseases
- Applicable for studying nasal congestion
- Used in research for allergic conjunctivitis and other allergic diseases
Cayman Chemical MK-1775, Purity: ≥98%, CAS: 955365-80-7, 10 mg
An inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM) that prevents phosphorylation of Cdc2 at tryosine15, which abrogates the G2 DNA damage checkpoint; induces apoptosis in combination with several DNA damaging agents selectively in p53-deficient tumor cell lines
Medchemexpress LLC Recombinant human glucokinase (GCK) protein | 9001-51-8 | >95.0% | 5 UG
Recombinant human glucokinase (GCK) protein supplied as a 5 μg research-grade enzyme. GCK catalyzes phosphorylation of D-glucose to glucose-6-phosphate and acts as a glucose sensor in pancreatic beta cells and the liver; the product is intended for in vitro research applications and should be handled and stored under recommended conditions.
- Recombinant human enzyme corresponding to amino acids L2-Q465.
- Expressed in Escherichia coli for recombinant production.
- Tag free to reduce assay interference.
- Purity >95% by reducing SDS-PAGE.
- Formulated in Tris-HCl, NaCl, 10% glycerol; 0.22 μm filtered.
- Store at -80°C and avoid repeated freeze-thaw cycles.
- Endotoxin <1 EU/μg (LAL method).
- Specific activity defined per unit at pH 8.0, 37°C.
Cayman Chemical WHI-P258, Purity: ≥98%, CAS: 21561-09-1, 5 mg
A negative control for JAK3 inhibition; molecular modeling estimated a Ki value of 72 µM; inactive at JAK3 (IC50 = >300 µM)
Selleck Chemical LLC Dehydroaripiprazole E7427-5MG
Dehydroaripiprazole is the active metabolite of aripiprazole primarily metabolized by CYP3A4 and CYP2D6 It inhibits glutamate release from rat prefrontocortical nerve terminals by activating dopamine D2 and 5-HT1A receptors reducing nerve terminal excitability and VDCC activation through a PKA-mediated signaling cascade potentially contributing to its neuroprotective effects in excitotoxic injury
Apexbio Technology LLC Ulipristal, 50mg. Cas: 159811-51-5 MFCD: MFCD19443756. progestogen receptor modulator
Ulipristal is a novel and selective progesterone receptor modulator (SPRM) for emergency contraception after an unprotected intercourse or contraceptive failure. Ulipristal can be used for the treatment of benign gynecological conditions such as uterine myoma [1]. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC CD9 Human HEK293 5ug
CD9 protein is an integral membrane protein that plays a critical regulatory role in processes such as sperm-egg fusion platelet activation and cell adhesion CD9 is critical for sperm-egg fusion coordinating multi-protein complexes on the oocyte surface CD9 Protein Human (HEK293 His) is the recombinant human-derived CD9 protein expressed by HEK293 with C-6 His labeled tag
Medchemexpress LLC Bifemelane hydrochloride (MCI-2016) | 62232-46-6 | 99.9% | 10 MM * 1 ML
Bifemelane hydrochloride (MCI-2016) is a potent, selective, and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. It also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has antidepressant activity and is used for research into cognitive and emotional disturbances related to cerebrovascular disease.
- Potent, selective, and competitive inhibitor of monoamine oxidase A (MAO-A)
- Inhibits MAO-B noncompetitively
- Antidepressant activity
- Used for research into cognitive and emotional disturbances related to cerebrovascular disease
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | MFCD01867746 | 98.0% | 20,000 (average) | (C2H4O)nC7H9NO5 | 5 MG
m-PEG-NHS ester (average MW 20,000) is a methoxy-terminated polyethylene glycol bearing an N-hydroxysuccinimide (NHS) ester functional group. It is designed for research use to introduce PEG chains onto amine-containing molecules, enabling PEGylation, bioconjugation, and use as a PEG-based linker for tasks such as PROTAC synthesis.
- Methoxy-terminated PEG with NHS ester for efficient amine coupling.
- Average molecular weight 20,000 for extended linker length and solubility enhancement.
- High purity (98.0%) suitable for research applications.
- Soluble in DMSO at approximately 175 mg/mL (ultrasonic recommended).
- Store sealed away from moisture and light at -20°C; in solvent store at -80°C for up to 6 months.
- Intended for research use only; not validated for medical applications.
Medchemexpress LLC Thiocolchicine | 100MG
Thiocolchicine a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50 2 5 M) and competitively binds to tubulin with a Ki of 0 7 M Thiocolchicine induces cell apoptosis[1][2] Thiocolchicine can be used as an ADC cytotoxin in ADC technology